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Nir Barzilai, M.D.

Professor, Medicine (Endocrinology)

Director, Institute for Aging Research

Director, Nathan Shock Center of Excellence in the Basic Biology of Aging

Ingeborg and Ira Leon Rennert Chair of Aging Research

AgingBiology of agingLongevity genes

Dr. Barzilai discovered the first “longevity gene” in humans. His research established that the gene variant that leads to high HDL, or “good cholesterol,” is linked to healthy aging and extreme longevity. Dr. Barzilai has been profiled by major outlets, including The New York Times, PBS’ “NOVA scienceNow” and National Geographic. read more...

Jill P. Crandall, M.D.

Professor, Department of Medicine (Endocrinology)

Jacob A. and Jeanne E. Barkey Chair in Medicine

Chief, Division of Endocrinology

Director, Fleischer Institute for Diabetes and Metabolism

DiabetesType 2 diabetesDiabetes prevention

Clinical TrialsPrediabetesResveratrol

An expert in diabetes prevention, Dr. Crandall is director of the Diabetes Clinical Trials Unit at Einstein and Montefiore and a principal investigator for several NIH-sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership), Glycemia Reduction Approaches in Diabetes (GRADE) and the PERL (Preventing Early Renal Loss) study. read more...

Betsy Herold, M.D.

Professor, Harold and Muriel Block Chair, Pediatrics

Professor, Microbiology & Immunology

Professor, Obstetrics & Gynecology and Women’s Health

Vice Chair, Research, Pediatrics, Einstein and the Children’s Hospital at Montefiore (CHAM)

Chief, Division of Pediatric Infectious Diseases, Einstein and CHAM

Infectious diseasesHerpes simplex virusesCOVID-19 and pediatricsVaccines and antiviralsHIV

Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.

Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies for young women and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.

Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.

Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.

Robert E. Michler, M.D.

Professor and Chair, Surgery, Einstein and Montefiore Health System

Professor and Chair, Cardiothoracic & Vascular Surgery, Einstein and Montefiore

Co-Director, Montefiore Einstein Center for Heart and Vascular Care

Surgeon-in-Chief, Montefiore

Cardiac surgeryMitral repair surgeryAortic valve surgery Minimally invasive heart surgeryHeart transplantation

Dr. Michler is a heart surgeon who specializes in complex aortic and mitral valve repair surgery. He is an NIH-funded investigator whose interest in repairing the injured heart has led to clinical trials in cardiac stem cell transplantation. Dr. Michler and his teams have advanced minimally invasive cardiothoracic surgery procedures and surgical robotics. This work led to FDA approval for selective cardiac robotic procedures including mitral valve repair and coronary bypass surgery. read more...

Vern L. Schramm, Ph.D.

Professor, Biochemistry

Ruth Merns Chair in Biochemistry

BiochemistryEnzymesTranslational medicine

RicinAutoimmune diseases

Dr. Schramm is a member of the National Academy of Sciences and associate editor of the Journal of the American Chemical Society. His pioneering work in biochemistry has resulted in powerful new strategies for treating cancer, antibiotic resistance and autoimmune diseases. read more...

Ulrich G. Steidl, Ph.D., M.D.

Professor, Cell Biology

Professor, Medicine

Deputy Director, Montefiore Einstein Comprehensive Cancer Center

Rose C. Falkenstein Chair in Cancer Research

Interim Director, The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research

Leukemias and myelodysplastic syndromes Pre-cancerous and cancer stem cellsCell and tumor biology

Dr. Steidl studies the molecular and cellular mechanisms that lead to two related blood diseases, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). His NIH-funded basic and translational research seeks to define the characteristics of pre-leukemic stem cells (pre-LSC), understand their progression to leukemic stems cells, and develop drug strategies to target the process. Dr. Steidl is co-director of the Montefiore Einstein Comprehensive Cancer Center's Blood Cancer Institute. read more...